2018 NCI IMAT PI Meeting

19th Annual Innovative Molecular Analysis
Technologies Principal Investigators Meeting


November 28-30, 2018
Hilton Washington DC/Rockville, Rockville, MD

Agenda

Day 1 – Wednesday, November 28th, 2018

9:00am

Welcome & Overview

Tony Dickherber, National Cancer Institute (NCI)

9:15am

Molecular Pathway Tools

9:15

Cancer Moonshot – Fusion Oncoproteins for Childhood Cancer Network (FusOnC2)

Keren Witkin, NCI

9:25

Protein Painting: Identification of Protein-Protein Interfaces for Drug Discovery

Lance Liotta, George Mason University

9:45

Multiplex In-Solution Protein Array (MISPA) for high-throughput, quantitative profiling of protein interactions in B-cell receptor pathway and detection of immune responses to multiple serotypes of HPV

Josh LaBaer, Arizona State University

10:05

An optimized design for single copy short hairpin RNAi

Scott Hammond, University of North Carolina, Chapel Hill

10:25

Development of proteasome adaptors to catalytically deplete specific proteins from cells

Andreas Matouschek, University of Texas, Austin

10:35

Novel Bi-functional Inhibitors Blocking OncomiR Biogenesis

Fu-Sen Liang, Case Western University

10:45am

Break

11:00am

New Approaches for Sample Preparation & Preservation

11:00

Development of Enhancer RNA-based Biomarkers in FFPE Tissue

Jason Gertz, University of Utah

11:20

Living Tumor Biopsies to Interrogate Immune Function and Response to Therapy

Matthew Krummel, University of California, San Francisco

11:40

Validation of a Room-Temperature Storage Technique for Plasma/Serum Biospecimens

Al Aksan, University of Minnesota

12:00

mSHEAR Technology for Cancer Cell Purification

Andrés Garcia and Susan Thomas, Georgia Institute of Technology

12:10

Label-free microfluidic enrichment of cancer cells from noncancer cells in ascites fluid

Todd Sulchek, Georgia Institute of Technology

12:20

Next-generation MOWChIP-seq for high-throughput epigenomic profiling using clinically relevant samples

Chang Lu, Virginia Tech

12:30pm

Lunch (on your own)

1:45pm

Invited Speaker

Sean Khozin, Ph.D.

Acting Deputy Director, Oncology Center of Excellence

Food & Drug Administration

1:15pm

Panel Discussion on Technology Translation and Transfer

Panelists:

  • Sean Khozin, Dep Dir, FDA/OCE
  • Michael Weingarten, Director, NCI Small Business Innovation Research Development Center
  • Tiffany Wilson, Executive Director, Global Center for Medical Innovation
  • Sergei Nachaev, ICorps PI, University of North Dakota
  • Mei He, ICorps PI, Clarivate Inc & University of Kansas
  • Mark Miller (moderator), Program Director, NCI Division of Cancer Prevention

3:00pm

Break

3:15pm

miRNA Detection Advances

3:15

Cancer Moonshot – Immuno-Oncology Translational Science Network (IOTN)

Elad Sharon, NCI

3:25

Noninvasive detection of circulating RNAs via tethered cationic lipoplex nanoparticles (tCLN) biochip for lung cancer early detection and prognosis

Yun Wu, State University of New York at Buffalo

3:45

A Solid-State Nanopore miRNA Quantification Technology

Hsueh-Chia Chang, University of Notre Dame

4:05

High Specificity MicroRNA Microarray Analysis without PCR for Cancer Screening and Research

Ravi Saraf, University of Nebraska, Lincoln

4:25

Single-molecule counting of cancer biomarker miRNAs in human biofluids

Nils Walter, University of Michigan

4:35pm

Poster Session I Highlights

Single-molecule mechanical detection of protein and microRNA cancer biomarkers

Wesley Wong, Boston Children’s Hospital

Nanoneedle microrobots for single cancer cell manipulation and genome editing

Rahim Esfandyarpour, Stanford University

High resolution cell lineage tracking and isolation

Amy Brock, University of Texas, Austin

High Content Screening of Multicellular Invasion with 3D Traction Force Microscopy

Ian Wong, Brown University

mCoil NMR platform for robust and high-throughput analysis of in vitro metabolic flux on living cells

Keyvan Keshari, Sloan-Kettering Institute for Cancer Research

5:00 – 7:00pm

Poster Session I

Advanced Imaging, -omic Profiling, Macromolecular Interaction Tools, Sample QA/QC, Synthetic Biology Tools, Novel Biosensors, Sample Preparation Tools

Dinner on your own

Day 2 – Thursday, November 29th, 2018

9:00am

Day 2 Kickoff

Tony Dickherber, National Cancer Institute (NCI)

9:05am

Technologies to Improve Drug Discovery & Development

9:05

NCI Specialized Programs of Research Excellence (SPORE)

Peter Ujhazy, NCI

9:20

Advanced Development and Validation of 3 Dimensional Spheroid Culture of Primary Cancer Cells using Nano3D Technology

Timothy Spicer, Scripps Florida

9:40

High-Throughput Screening Under Static or Dynamic Hypoxia

Michael Gamcsik, North Carolina State University

10:00

Charge sensitive optical detection for high-throughput study of small molecules

Nongjian Tao, Arizona State University

10:20

Genome-wide identification and targeting of resistance to cancer therapy

Eytan Ruppin, University of Maryland, College Park

10:30am

Break

10:45am

Next Generation Clinical Diagnostic Technologies

10:45

High Throughput GO Chip isolation of Lung CTCs for Molecular Diagnosis and Drug Testing

Sunitha Nagrath, University of Michigan

11:05

Analysis of scant cancer cells in fine needle aspirates

Ralph Weissleder, Massachusetts General Hospital

11:25

Validation of a Microdissection Method to Advance Precision Medicine

Donald Johann and Michael Tangrea, University of Arkansas for Medical Sciences

11:45

A Novel Molecular Assay for Early Detection and Assessment of Cancer Risk

Lurdes Queimado, University of Oklahoma Health Sciences Center

12:05

Validating Rapid Microfluidic Isolation of Personalized Aptamers for Monitoring Minimal Residual Disease in Multiple Myeloma

Qiao Lin, Columbia University

12:15pm

Lunch (on your own)

1:30pm

Cancer Modeling Advances

1:30

Cancer Moonshot – Pediatric Immunotherapy Discovery and Development Network

(P-IDDN)

Nita Seibel, NCI

1:40

Bioengineered Lung Tumor Organoids for Development of Personalized Medicine

Aleksander Skardal, Wake Forest University Health Sciences

2:00

A Genetic Toolbox for the Identification and Interrogation of Tumor Cells of Origin, Propagation, and Recurrence from Patient-derived Oncogenic Drivers

Joshua Breunig, Cedars-Sinai Medical Center

2:20

LETSSGo: Lymphoma-on-chip Engineered Technology for Single-Organoid Sequencing and Genomics

Ankur Singh, Cornell University

2:30pm

Imaging Probes I

2:30

Cancer Moonshot – Human Tumor Atlas Network (HTAN)

Sean Hanlon, NCI

2:45

Combinatorial Fluorescence with Spectral Imaging

Marc Birtwistle, Clemson University

3:05

A Highly Multiplexed Gene Expression Platform for Fixed Tissue Specimens

H. Benjamin Larman, Johns Hopkins University

3:25

Transforming FLIM into a high-content molecular analysis platform

Jered Haun, University of California – Irvine

3:35pm

Break

3:55pm

Imaging Probes II

3:55

No-Carrier Added Electrochemical Radio-Fluorination

Saman Sadeghi, University of California Los Angeles

4:10

High-throughput radiochemistry platform for accelerated discovery and development of novel PET imaging agents for cancer

Michael van Dam, University of California Los Angeles

4:25

GESI: a novel technology for functional imaging in living cells

Kit Lam, University of California at Davis

4:35

Translational Molecular and Cellular Imaging Technologies for Prostate Tumor Pathology

Andrew Smith, University of Illinois at Urbana-Champaign

4:45pm

Poster Session II Highlights

A novel time-resolved fluorescence-based high-throughput screening technology for discovering allosteric kinase inhibitor

Nicholas Levinson, University of Minnesota

Monitoring Recurrent Bladder Cancer with Electro-Phage Biosensors

Greg Weiss, University of California – Irvine

Multiplex FRET Imaging of Kinase-Epigenome Interregulations in Live Cancer Cells

Yingxiao Wang, University of California, San Diego

A Self-Assembling Peptide Nanofiber Matrix for Prostate Cancer Cell Organoid Growth

Donald Vander Griend, University of Chicago

Multiplex FRET Imaging of Kinase-Epigenome Interregulations in Live Cancer Cells

Yingxiao Wang, University of California, San Diego

A Self-Assembling Peptide Nanofiber Matrix for Prostate Cancer Cell Organoid Growth

Donald Vander Griend, University of Chicago

Development of Novel Chemical Probes to Map S-Nitrosylation in Cancer

Jason Held, Washington University

Tunable Fluorescent Organic Nanoparticles for Cancer Imaging Applications

Aaron Mohs, University of Nebraska Medical Center

5:15 – 7:00pm

Poster Session II

Cancer Modeling Advances, Liquid Biopsy Technologies, Imaging Agents, Mass Spectrometry, Immunotherapy Tools, Mechanobiology, Clinical Diagnostics, and presentations from guests supported by the American Cancer Society

Dinner on your own

 

Day 3 – Friday, November 30th, 2018

9:00am

Day 3 Kickoff

Tony Dickherber, National Cancer Institute (NCI)

9:05am

Single Cell Analysis Technologies

9:05

Cancer Moonshot – Drug Sensitivity and Resistance Network (DSRN)

Michael Espey, NCI

9:15

Clinical implementation of single cell tumor transcriptome analysis

Aviv Regev, Broad Institute, Inc

9:35

Optical Demultiplexing for Large-Scale Integration of Imaging and Single Cell RNA-Seq

Peter Sims, Columbia University Health Sciences

9:55

Single Cell Cytokine Analysis of Circulating Malignant Hematopoietic Cells

Rong Fan, Yale University

10:15

Multiplet analysis and lineage tracing for single cell cancer genomics

Allon Klein, Harvard Medical School

10:25am

Break

10:45am

Advances in Mass Spectrometry

10:45

Mass Spectrometry Detection of Drugs in Single Bladder Cancer Cells from Patients Anthony Burgett, University of Oklahoma

11:05

In-Depth Proteome Mapping of the Tumor Microenvironment with Single-Cell Resolution

Ryan Kelly, Pacific Northwest National Laboratories

11:25

Online Raman Diagnostics of Oncometabolites

Zachary Schultz, The Ohio State University

11:45

Measurement of Aberrant Protein Folds in Malignant Cells with Proteomics and Mass Spectrometry

Casimir Bamberger, Scripps Research Institute

11:55am

Closing Remarks

Tony Dickherber, NCI

Meeting Adjourned at 12pm