2018 NCI IMAT PI Meeting

19th Annual Innovative Molecular Analysis
Technologies Principal Investigators Meeting


November 28-30, 2018
Hilton Washington DC/Rockville, Rockville, MD

Active Projects

Actv PI Name(s) All Institution Project Title
R33 AKSAN, ALPTEKIN UNIVERSITY OF MINNESOTA Validation of a Room-Temperature Storage Technique for Plasma/Serum Biospecimens
R33 BHARGAVA, ROHIT  (contact); CHEVILLE, JOHN C UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN Translational Molecular and Cellular Imaging Technologies for Prostate Tumor Pathology
R21 BHATNAGAR, PARIJAT SRI INTERNATIONAL Cellular biofactories for therapeutic protein synthesis in tumor microenvironment
R21 BIRTWISTLE, MARC R CLEMSON UNIVERSITY Multiplexed, Quantitative Fluorescence Imaging in Tumor Sections
R33 BORGES, CHAD THE BIODESIGN INSTITUTE AT ARIZONA STATE UNIVERSITY Validation and Advanced Development of Albumin Oxidizability as a Marker of Plasma/Serum Integrity
R21 BRENT, ROGER FRED HUTCHINSON CANCER RESEARCH CENTER Precision controllers of mammalian gene expression
R33 BREUNIG, JOSHUA JOHN CEDARS-SINAI MEDICAL CENTER A Genetic Toolbox for the Identification and Interrogation of Tumor Cells of Origin, Propagation, and Recurrence From Patient-derived Oncogenic Drivers
R21 BROCK, AMY UNIVERSITY OF TEXAS, AUSTIN High resolution cell lineage tracking and isolation
R33 BROWN, JONATHAN QUINCY TULANE UNIVERSITY OF LOUISIANA Improving biospecimen quality by verifying adequacy at the point-of-acquisition with ex vivo structured illumination microscopy
R21 BURGETT, ANTHONY WG UNIVERSITY OF OKLAHOMA NORMAN Mass Spectrometry Detection of Drugs in Single Bladder Cancer Cells from Patients
R21 CARPENTIERI, DAVID  (contact); PIRROTTE, PATRICK PHOENIX CHILDREN’S HOSPITAL Preservation of Dried Plasma Spots for downstream proteomic applications
R21 CHANG, HSUEH-CHIA  (contact); SENAPATI, SATYAJYOTI ; SHAH, SUNNY SATISH UNIVERSITY OF NOTRE DAME A Solid-State Nanopore miRNA Quantification Technology
R33 CIMA, MICHAEL J MASSACHUSETTS INSTITUTE OF TECHNOLOGY Advanced development and validation of microdevices for high-throughput in situ drug sensitivity testing in tumors
R21 DAVIS, RONALD WAYNE STANFORD UNIVERSITY Nanoneedle microrobots for single cancer cell manipulation and genome editing
R21 DICKINSON, BRYAN UNIVERSITY OF CHICAGO rePPI-i: A system for the rapid continuous evolution of protein-protein interaction inhibitors
R21 EASWARAN, HARIHARAN  (contact); PISANIC II, THOMAS RUSSELL JOHNS HOPKINS UNIVERSITY High-efficiency microfluidic-assisted single-cell DNA methylome sequencing
R21 ENGLER, ADAM JEFFREY UNIVERSITY OF CALIFORNIA, SAN DIEGO Developing Adhesome Technology as a Physical Marker of Highly Metastatic Cells
R33 FAN, RONG  (contact); LEVINE, ROSS L YALE UNIVERSITY Single cell cytokine analysis of circulating malignant hematopoietic cells
R21 FIELDS, RYAN C WASHINGTON UNIVERSITY Advancing Cancer Biology, Diagnostics and Therapeutics Outside of the Patient: Creation of a Novel, Autologous, Ex Vivo, Vascularized Model of the Tumor Microenvironment
R21 GAMCSIK, MICHAEL NORTH CAROLINA STATE UNIVERSITY RALEIGH High-Throughput Screening Under Static or Dynamic Hypoxia
R21 GAO, XIAOHU UNIVERSITY OF WASHINGTON Cancer molecular analysis using quantum dots
R21 GARCIA, ANDRES J (contact); THOMAS, SUSAN NAPIER GEORGIA INSTITUTE OF TECHNOLOGY uSHEAR Technology for Cancer Cell Purificaiton
R21 GERTZ, JASON UNIVERSITY OF UTAH Development of Enhancer RNA-based Biomarkers in FFPE Tissue
R21 HALL, ADAM ROGER WAKE FOREST UNIVERSITY HEALTH SCIENCES Molecular Detection of DNA Hydroxymethylation for Cancer Screening
R21 HAMMOND, SCOTT M UNIV OF NORTH CAROLINA CHAPEL HILL An optimized design for single copy short hairpin RNAi
R21 HAUN, JERED BRACKSTON UNIVERSITY OF CALIFORNIA-IRVINE Transforming fluorescence lifetime imaging microscopy into a fast and simple platform for high-content molecular analysis
R21 HELD, JASON M (contact); BIRMAN, VLADIMIR B WASHINGTON UNIVERSITY DEVELOPMENT OF NOVEL CHEMICAL PROBES TO MAP S-NITROSYLATION IN CANCER
R21 HERR, AMY UNIVERSITY OF CALIFORNIA BERKELEY MICROFLUIDIC WESTERN BLOTTING FOR TARGETED PROTEOMIC ANALYSIS OF SINGLE CIRCULATING TUMOR CELLS
R33 IBRAHIM, YEHIA BATTELLE PACIFIC NORTHWEST LABORATORIES High Resolution High Throughput Proteomics Platform for Cancer Research
R33 INCE, TAN A UNIVERSITY OF MIAMI SCHOOL OF MEDICINE Live Tumor Culture Core and Tissue Specific Culture (TSC) System for Human Cancers
R33 ISSADORE, DAVID AARON UNIVERSITY OF PENNSYLVANIA Rapid unbiased isolation and in situ RNA analysis of circulating tumor cells using a magnetic micropore-based diagnostic chip
R21 JAHNKE, FRANK SONATA BIOSCIENCES, INC. A New Sample Preparation Method to Delve Deeper into the Proteome
R33 JIANG, NING UNIVERSITY OF TEXAS, AUSTIN An integrated therapeutic T cell receptor screening platform for adoptive cell therapy in cancer
R21 KARGINOV, ANDREI V UNIVERSITY OF ILLINOIS AT CHICAGO Engineered regulation of tyrosine phosphatase activity in living cells
R21 KARGINOV, ANDREI V (contact); REHMAN, JALEES UNIVERSITY OF ILLINOIS AT CHICAGO Optogenetic tools for the dissection of oncogenic signaling mediated by kinases
R33 KELLEY, SHANA O UNIVERSITY OF TORONTO Development and validation of nanoparticle-mediated microfluidic profiling approach for rare cell analysis
R21 KESHARI, KAYVAN R SLOAN-KETTERING INST CAN RESEARCH uCoil NMR platform for robust and high-throughput analysis of in vitro metabolic flux on living cells
R33 KLEIN, ALLON MOSHE HARVARD MEDICAL SCHOOL Droplet microfluidic technology for single cell cancer genomics
R33 KONRY, TANIA TALI (contact); EVENS, ANDREW M; HUANG, TONY JUN NORTHEASTERN UNIVERSITY Determining treatment sensitivity in B cell lymphoma by novel microfluidics-based NK cell immunogenicity platform
R21 KRON, STEPHEN J UNIVERSITY OF CHICAGO Tag-ChIP-MS for analysis of chromatin-level regulation of DNA repair
R21 KRUMMEL, MATTHEW F UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Living Tumor Biopsies to Interrogate Immune Function and Response to Therapy
R21 LABAER, JOSHUA ARIZONA STATE UNIVERSITY-TEMPE CAMPUS Multiplexed In Solution Protein Array (MISPA) for identifying novel protein interactions in cancer and for early detection of immune responses in pathogen-induced cancers
R33 LAM, KIT S UNIVERSITY OF CALIFORNIA AT DAVIS GESI: a novel technology for functional imaging in living cells
R21 LARMAN, HARRY BENJAMIN JOHNS HOPKINS UNIVERSITY A Highly Multiplexed Gene Expression Platform for Fixed Tissue Specimens
R33 LEVENSON, RICHARD M UNIVERSITY OF CALIFORNIA AT DAVIS Cancer histology and QC via MUSE: Sample-sparing UV surface-excitation microscopy
R21 LEVINSON, NICHOLAS MARK UNIVERSITY OF MINNESOTA A novel time-resolved fluorescence-based high-throughput screening technology for discovering allosteric kinase inhibitors
R21 LIANG, FU-SEN UNIVERSITY OF NEW MEXICO Novel Bi-functional Inhibitors Blocking OncomiR Biogenesis
R33 LIN, QIAO COLUMBIA UNIV NEW YORK MORNINGSIDE Validating Rapid Microfluidic Isolation of Personalized Aptamers for Monitoring Minimal Residual Disease in Multiple Myeloma
R33 LIOTTA, LANCE ALLEN GEORGE MASON UNIVERSITY Protein painting identifies therapeutic targets at protein-protein interfaces
R33 LIU, YANG UNIVERSITY OF PITTSBURGH AT PITTSBURGH High-throughput super-resolution imaging of chromatin structures at different epigenetic states
R33 LU, CHANG VIRGINIA POLYTECHNIC INST AND ST UNIV Next-generation MOWChIP-seq for high-throughput epigenomic profiling using clinically relevant samples
R33 LU, JUN YALE UNIVERSITY CRISPR-based Enhanced Molecular Chipper Technology for Identifying Functional Noncoding Elements in Cancer
R21 MACCOSS, MICHAEL UNIVERSITY OF WASHINGTON Systematic and Comprehensive Sampling of Peptides in Mixtures by Tandem Mass Spectrometry
R21 MAILLOUX, ADAM WILLIAM H. LEE MOFFITT CANCER CTR & RES INST Autohistomagnetic Isolation of Tumor-reactive T-cells
R33 MAKRIGIORGOS, G MIKE DANA-FARBER CANCER INST Maximum efficiency sequencing using nuclease-based mutation enrichment and digital barcodes
R21 MALMSTADT, NOAH  (contact); ROBERTS, RICHARD W UNIVERSITY OF SOUTHERN CALIFORNIA A Target-Directed Reagent Pipeline via Microfluidic mRNA Display
R21 MATOUSCHEK, ANDREAS UNIVERSITY OF TEXAS, AUSTIN Development of proteasome adaptors to catalytically deplete specific proteins from cells
R21 MEHTA, ANAND S (contact); HAAB, BRIAN B MEDICAL UNIVERSITY OF SOUTH CAROLINA Glyco-typer: an antibody capture glycan imaging methodology
R21 MOHS, AARON M UNIVERSITY OF NEBRASKA MEDICAL CENTER Tunable Fluorescent Organic Nanoparticles for Cancer Imaging Applications
R21 NAEGLE, KRISTEN M WASHINGTON UNIVERSITY A MOLECULAR TOOLKIT FOR THE PRODUCTION OF TYROSINE PHOSPHORYLATED PROTEINS
R33 NAGRATH, SUNITHA  (contact); RAMNATH, NITHYA UNIVERSITY OF MICHIGAN High Throughput GO Chip isolation of Lung CTCs for Molecular Diagnosis and Drug Testing
R21 NECHAEV, SERGEI UNIVERSITY OF NORTH DAKOTA Transcriptome profiling of highly degraded specimens through global analysis of short RNA fragments.
R33 PARKER, LAURIE L UNIVERSITY OF MINNESOTA Fluorescence lifetime-based single fluorophore biosensors of post-translational modification enzyme activity
R33 PATTENDEN, SAMANTHA GAIL (contact); DAVIS, IAN J; DAYTON, PAUL A UNIV OF NORTH CAROLINA CHAPEL HILL The application of Enhanced Cavitation to enable DNA and Chromatin Extraction from Archived Tissues
R21 PAULOVICH, AMANDA G FRED HUTCHINSON CANCER RESEARCH CENTER Validation of a disposable biospecimen collection system with integral refrigeration for preserving the phosphoproteome
R21 PRATX, GUILLEM STANFORD UNIVERSITY High-throughput radionuclide counting and sorting of single cells
R33 QUEIMADO, MARIA DE LURDES LURDES UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR A novel molecular assay for early detection and assessment of cancer risk
R33 RAPPAPORT, STEPHEN MORRIS UNIVERSITY OF CALIFORNIA BERKELEY Using Adductomics to Characterize Exposures to Carcinogens
R21 RECHT, MICHAEL PALO ALTO RESEARCH CENTER High-throughput screening platform for cancer drug discovery
R33 REGEV, AVIV  (contact); JOHNSON, BRUCE E BROAD INSTITUTE, INC. Clinical implementation of single cell tumor transcriptome analysis
R21 ROBLES, FRANCISCO E GEORGIA INSTITUTE OF TECHNOLOGY Stimulated Raman scattering spectroscopic optical coherence tomography (SRS-SOCT) for label-free molecular imaging of brain tumor pathology
R21 SADEGHI, SAMAN UNIVERSITY OF CALIFORNIA LOS ANGELES Electrochemical Synthesis of Radiopharmaceuticals
R33 SALIPANTE, STEPHEN J UNIVERSITY OF WASHINGTON Advanced development and validation of genome-scale molecular diagnostics for microsatelliteinstability using targeted molecular counting methods
R21 SARAF, RAVI F UNIVERSITY OF NEBRASKA LINCOLN High Specificity MicroRNA Microarray Analysis without PCR for Cancer Screening and Research
R33 SCHULTZ, ZACHARY UNIVERSITY OF NOTRE DAME Online Raman Diagnostics of Oncometabolites
R21 SHI, TUJIN BATTELLE PACIFIC NORTHWEST LABORATORIES An ultrasensitive targeted mass spectrometry system for proteomics analysis of single cells
R33 SIMS, PETER ALAN COLUMBIA UNIVERSITY HEALTH SCIENCES Large-Scale Integration of Single Cell RNA-Seq and High-Content Imaging for Analyzing Drug Response in Cancer
R33 SINGH, ANKUR CORNELL UNIVERSITY LETSSGo: Lymphoma-on-chip Engineered Technology for Single-Organoid Sequencing and Genomics
R21 SLATER, JOHN HUNDLEY UNIVERSITY OF DELAWARE A Vascularized, In Vitro, Organotropic Metastasis Model to Generate Dormant Micrometastases
R21 SMITH, LLOYD M UNIVERSITY OF WISCONSIN-MADISON Novel NeuCode Tagging Reagents for Identification and Quantification of Intact Proteoforms in Cancer Tissues
R21 SOELLNER, MATTHEW B UNIVERSITY OF MICHIGAN Exquisitely selective turn-on probes of kinase activation and localization
R33 SOKER, SHAY WAKE FOREST UNIVERSITY HEALTH SCIENCES Bioengineered Lung Tumor Organoids For Development Of Personalized Medicine
R33 SPICER, TIMOTHY PATRICK SCRIPPS FLORIDA Advanced Development and Validation of 3 Dimensional Spheroid Culture of Primary Cancer Cells using Nano3D Technology
R21 SULCHEK, TODD  (contact); MCDONALD, JOHN F GEORGIA INSTITUTE OF TECHNOLOGY Label-free microfluidic enrichment of cancer cells from noncancer cells in ascites fluid
R33 TAO, NONGJIAN ARIZONA STATE UNIVERSITY-TEMPE CAMPUS Charge sensitive optical detection for high-throughput study of small molecules
R21 VAN DAM, ROBERT MICHAEL UNIVERSITY OF CALIFORNIA LOS ANGELES High-throughput radiochemistry platform for accelerated discovery and development of novel PET imaging agents for cancer
R21 VAN DEVENTER, JAMES ALLEN TUFTS UNIVERSITY MEDFORD Discovering hybrid inhibitors for tumor microenvironment disruption
R21 VANDER GRIEND, DONALD JAMES (contact); COLLIER, JOEL H UNIVERSITY OF CHICAGO Supramolecular matrix materials for prostate cancer cell biology
R21 VO-DINH, TUAN DUKE UNIVERSITY Nanoplasmonics-based molecular analysis tool for molecular biomarkers of cancer
R33 WALTER, MATTHEW J (contact); DUNCAVAGE, ERIC J WASHINGTON UNIVERSITY TARGETED SINGLE-MOLECULE SEQUENCING ASSAY INCORPORATING MOLECULAR BARCODES
R21 WALTER, NILS G UNIVERSITY OF MICHIGAN Single-molecule counting of cancer biomarker miRNAs in human biofluids
R33 WANG, YINGXIAO UNIVERSITY OF CALIFORNIA, SAN DIEGO Multiplex FRET Imaging of Kinase-Epigenome Interregulations in Live Cancer Cells
R33 WEISS, GREGORY A UNIVERSITY OF CALIFORNIA-IRVINE Monitoring Recurrent Bladder Cancer with Electro-Phage Biosensors
R33 WEISSLEDER, RALPH MASSACHUSETTS GENERAL HOSPITAL Analysis of scant cancer cells in fine needle aspirates
R21 WELJIE, AALIM M UNIVERSITY OF PENNSYLVANIA Determining and enhancing metabolite fitness for metabolomics measurements
R21 WELSH, JOHN T VACCINE RESEARCH INSTITUTE OF SAN DIEGO A molecular method to determine isoform frequencies in RNA-seq
R21 WINDLE, BRAD E (contact); DEB, SUMITRA VIRGINIA COMMONWEALTH UNIVERSITY The GOF Mutant p53 Beacon System
R21 WONG, IAN Y BROWN UNIVERSITY High Content Screening of Multicellular Invasion with 3D Traction Force Microscopy
R21 WONG, WESLEY PHILIP BOSTON CHILDREN’S HOSPITAL Single-molecule mechanical detection of protein and microRNA cancer biomarkers
R33 WU, YUN STATE UNIVERSITY OF NEW YORK AT BUFFALO Noninvasive detection of circulating RNAs for lung cancer early detection and prognosis
R33 YATES, JOHN R SCRIPPS RESEARCH INSTITUTE Measurement of Aberrant Protein Folds in Malignant Cells with Proteomics and Mass Spectrometry
R21 YEH, HSIN-CHIH (contact); DUNN, ANDREW K UNIVERSITY OF TEXAS, AUSTIN An integrated imaging tool for probing EGFR subcellular trafficking in real time
R33 ZENG, YONG  (contact); GODWIN, ANDREW K; SAMUEL, GLENSON UNIVERSITY OF KANSAS LAWRENCE Integrated exosomes profiling for minimally invasive diagnosis and monitoring of cancer
R33 ZILBERBERG, JENNY  (contact); LEE, WOO YOUNG HACKENSACK UNIVERSITY MEDICAL CENTER Ex vivo culture platform validation for preservation of patient derived multiple myeloma cells